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The incidence of non-contact knee injury was found higher in female than in male and is related to the phases of the menstrual cycle. This raised the possibility that female sex-steroids are involved in the mechanism underlying this injury via affecting the expression of the receptors for relaxin, a peptide hormone known to modulate ligament laxity. Therefore, this study aims to investigate the effect of sex-steroids on relaxin receptor isoforms (RXFP1 &amp; RXFP2) expression in the ligaments and tendons of the knee.

international journal of medical sciences

Sex-Steroid Regulation of Relaxin Receptor Isoforms (RXFP1 &amp; RXFP2) Expression in the Patella Tendon and Lateral Collateral Ligament of Female WKY Rats