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: Regenerative capacity of the heart is limited, and the post-infarct left ventricle (LV) dysfunction is associated with poor prognosis. Administration of stem/progenitor cells (SPCs) is a promising approach for cardiac regeneration. Objectives : In the study, we assessed LV function and post-infarcted remodeling in patients with ST-elevated myocardial infarct (STEMI) who received autologous lineage-negative (LIN - ) SPCs. Patients and methods : Patients with STEMI and one-vessel coronary artery disease treated with percutaneous revascularisation were divided into study group (LIN - group, 15 patients) that received standard therapy and autologous BM-derived LIN - SPCs and control group (standard therapy group, 19 patients). The cells were administered intracoronary 24 hours after STEMI. The follow-up was 12 months with subsequent non-invasive tests and laboratory parameter evaluation on days 1 st , 3 rd , and 7 th as well as at 1 st , 3 rd , 6 th and 12 th month after STEMI. Results : All procedures related to SPCs administration were well tolerated by the patients. In 12-month follow-up, there were no major adverse cardiac events connected with LIN - SPCs administration. During 12-month follow-up, 9 patients from LIN - group (Responders) achieved an improvement in LV ejection fraction (&gt;10% after 12 months) with no signs of unfavorable LV remodeling. Laboratory parameters analysis showed that Troponin T levels were significantly lower until day 7 th in the Responders group, while brain natriuretic peptide (BNP) level remained significantly lower from day 3 rd to 12 th month respectively. Conclusions : Intracoronary infusion of autologous BM-derived LIN - stem/progenitor cells is feasible and safe for patient. Improvement in LV function and prevention of unfavorable remodeling in the 60% of study group seems relatively promising. Stem cell-based therapy for cardiac regeneration still needs more accurate and extensive investigations to estimate and improve their efficacy.

international journal of medical sciences

The Effect of Intracoronary Infusion of Autologous Bone Marrow-Derived Lineage-Negative Stem/Progenitor Cells on Remodeling of Post-Infarcted Heart in Patient with Acute Myocardial Infarction