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In Europe and the United States, several large-scale clinical studies have been conducted regarding the development of atherosclerotic cardiovascular diseases, including how dyslipidemia is involved in atherosclerosis and how treatment approaches affect these disease. These results suggest that gender differences might exist in the development of dyslipidemia and atherosclerotic cardiovascular diseases. Considering these facts, men and women should have separate therapeutic procedures for dyslipidemia, which has led to the creation of separate treatment guidelines since the 1990s. In the cohort study in Japan, there are few studies that indicated dyslipidemia as a risk factor for cerebrovascular disease, and such Japanese outcome studies that evaluated stroke and/or cerebral infarction did not include hypercholesterolemia as one of risk factors. Japanese cohort studies that incorporated both LDL-C and high density lipoprotein cholesterol (HDL-C) which are important for settling the management target values of dyslipidemia as predictive indices, and that included both myocardial infarction and onset of coronary artery disease widely as outcome were only Suita study and Hisayama study. In Japan the proportion of stroke in cerebrovascular disease is high, and in fact, the ratio of stroke and coronary artery disease in Hisayama study was 2:1; however, the proportion of atherothrombotic cerebral infarction which results from high LDL-C as the main risk factor is less than 20%. From the viewpoint that the risk assessment of dyslipidemia can be evaluated finely from five ranks of LDL-C, Japan Atherosclerosis Society (JAS) selected results of Suita study to assess the absolute risk for the primary prevention of Japanese general adult population. By using Suita score to stratify the risk for developing coronary artery disease in 10 years, JAS published “JAS Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2017”.

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Medical care for dyslipidemia in women based on the “Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2017”