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cells The use of SICM showed the dependence of the nucleus mechanical properties on the amount of lamin A and its isoforms Therefore, the mechanical properties of the NE have tight relationship with molecular composition of NL Thus, the cell nuclei expressing the additional lamin A gene were found to be 13 times more rigid than the wild-type cell nuclei, and changes in the structure of lamin A lead to improper organization of the nuclear skeleton These may be due to the polymerization abnormality of dimers and decreased network stability and/or sequestration of normal protein

biopolymers and cell

Irradiation by γ-rays reduces the level of H3S10 phosphorylation and weakens the G2 phase-dependent interaction between H3S10 phosphorylation and γH2AX