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in colorectal cancer cells by decreasing the sensitivity of DLD1 cells to combination anticancer drugs used in clinics for the treatment of colorectal cancer, oxaliplatin and 5-fluouracil Analysis of accumulation of senescenceassociated beta-galactosidase showed that neither DLD1, nor DLD1-Wip1ON cells don not develop senescent phenotype and their resistance is not based on induction of senescence To prove that resistance of DLD1-Wip1ON cells occur due to Wip1 overexpression, we created DLD1-Wip1KO cell line with bi-allellic knockout of Wip1 gene The opposite effect was observed in cells with deletion of Wip1 making them more sensitive to combination of DNA damaging drugs Conclusions: Overexpression and deletion of nuclear phosphatase Wip1 affects DNA damage response in colorectal cancer cells induced by a classical combination of chemotherapeutic drugs used for FOLFOX adjuvant therapy of colorectal cancer

A novel approach in studies of the posttranslational modification effect on YB-1 translocation