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initiation zones Our data verify the previously proposed model of the spatio-temporal organization of replication in Drosophila chromosomes (Kolesnikova et al., 2018) and indicate that the multi-stranded nature of PCh provides a unique opportunity to visualize in one chromosome the stochastic initiation of replication in some regions of the chromosomes, as well as the effective initiation of replication in other sites

Polyploidy reprograms regulatory pathways towards unicellular mode: the role in stress response, drug resistance, growth and cancer