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Eutheria, gen er ally re garded as the pla cen tal, be long to the most ad vanced mam ma lian infraclass [1]. Un like Monotremata and Marsupialia, Eutheria are spe cific for a more ad vanced re pro duc tive sys tem, which al lows them to oc cupy var i ous eco log i cal niches and to spread to dif fer ent cli ma tic zones. In the ar eas where Monotremata and Marsupialia tried com pet ing Eutheria, usu ally, the pref er ence was given to the rep re sen ta tives of the lat ter. Both the data of palaeontological re searches and the data of ecol o gists, who ob served the pro cess of mam ma lian colo nis ation of Aus tra lian con ti nent, tes tify to the men tioned fact [1]. Al though the pres ence of pla centa is con sid ered to be a spe cific fea ture of higher mam mals, pla centa is also pres ent in some Lacerta, Serpentes, and Marsupialia [1, 3]. Yet in Eutheria only, the pro cess of pla centa for ma tion is pre ceded by the pe riod of periimplantation [3]. Periimplantation in mam ma lian fe male spec i men is char ac ter ised by the se ries of mor pho log i cal and phys i o log i cal changes in uterus and em bryo [3–6]. Com plete in for ma tion on these events is pre sented in the re search data on murine ro dents [3, 4]. A num ber of meth ods, aimed at the in ves ti ga tion of events which con di tion the course of the periimplantation and its fi nal stage – the im plan ta tion on mo lec u lar-ge netic level were elab o rated [7]. The ap pli ca tion of these meth ods al lowed ob tain ing the gen eral rep re sen ta tion of he red i tary programmes and mo lec u lar ways of reali sa tion of these programmes, as so ci ated with the afore men tioned pro cess. As a re sult it has been re vealed that, the events, con nected with prep a ra tion and suc cess ful con clu sion of periimplantation, are de pend ent sig nif i cantly on the “di a logue” be tween the em bryo and the uterus on the cell-mo lec u lar level [8–10]. This kind of “di a logue” is to ini ti ate uterus sus cep ti bil ity and the de gree of em bryo readi ness to be im planted [3, 10, 11]. The pe riod of sus cep ti bil ity is lim ited in time [3, 4, 10] and uterus en vi ron ment is ca pa ble of main tain ing blastocyst growth, at tach ment, and sub se quent im plan ta tion [3, 12]. Ovar ian ste roids – progesterones and/or estrogens – are con sid ered to be the main fac tors de ter min ing uterus sus cep ti bil ity. How ever, if the im plan ta tion in mice and rats de pends on both hor mones, then in mustelids, pigs, Guinea pigs, rab bits, and cricetids the men tioned pro cess is en sured by pro ges ter one only [3, 4, 13, 14].

Periimplantation subprogram for morphogenesis – the evolutionary know-how of eutherians