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Application of high concentrations of antistaphylococcal antibiotic batumin in order to increase biosynthetic activity of the own antibiotic producing strain allowed selecting variants with increased productivity. Clone Pseudomonas batumic No.9 with maximum activity synthesized from 60 to 70 mg of batumin per l of culture medium, which was 2 times higher than the activity of the most productive natural producing strain However, after storage of this culture in non-selective conditions we noticed gradual decrease in the activity. Chlortetracyclin possesses only selective influence, the result of which was raise in the content of clones with the increased activity in producing strain population.

Impact of inductive and selective agents on biosynthesis of new antistaphylococcal antibiotic batumin