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Detection of double-stranded DNA (dsDNA) and single-strcnded DNA (ssDNA) and UNA with two new cyanine dyes Cyan 13 and Cyan 40 is reported. Cyan 13 and Cyan 40 bind to nucleic acids to form a stable fluorescent complexes and can be used for the detection of DMA and RNA samples separated by gel electrophoresis. Sensitivity of detection is comparable to tl at for ethidium bromide (EtBr), a common nucleic acid staining dye.

Interaction of cyanine dyes with nucleic acids. 3. The of new cyanine dyes Cyan 13 and Cyan 40 for detection of nucleic acids in agarose gel