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Highly effective permeabilizationltranslation system developed recently (Negrutskii et al (1994) Proc. Nat Acad. Sci. USA 91, 964—968} was used to study the distribution of FIT С-labeled a and д subunits of translation elongation factor 1 in human fibroblasts. Somewhat granular fluorescent picture observed for the both proteins distribution during active protein synthesis may be indicative of putative protein synthesis compartments. Exogenous phosphocreatine, an absolutely required agent to support the protein synthesis in permeabilized cells, is shown to influence the EF-la distribution, while not affecting the EF-16. Most of EF-la under «low energy» condition is found in nucleus. Thus, the possibility of the functional change in EF-la distribution is demonstrated supporting the idea about transient character of EF-la involvement into «heavy» EF-1 complex.

The effect of phosphocreatine on the distribution of different subunits of translation elongation factor 1 in gently permeabilized human fibroblasts