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D-mannose was shown to induce disaggregation of rat thymocytes and E. coli ЛВ1157 cells at any stage of the process. Mannose-specific aggregation of thymocytes and E. coli was inhibited by heating as opposed to concanavalin A-induced thymocyte aggre­ gation. The process was completely reversible at the rapid temperature changes, indi­ cating its membrane not intracellular mechanism. Taken together, the results demonstra­ te that mannose-specific intercellular contacts can be affected differently by temperature.

Mannose-specific intercellular aggregation of rat thymocytes and Escherichia coli cells triggered by temperature