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Functional magnetic resonance imaging (fMRI) has, since its de- scription fifteen years ago, become the most common in-vivo neuroimaging technique. FMRI allows the identification of brain areas which are related to specific tasks, by statistical analysis of the BOLD (blood oxigenation level dependent) signal. Classically, the observed BOLD signal is compared to an expected haemodynamic response function (HRF) using a general linear model (GLM). However, the results of GLM rely on the HRF specification, which is usually determined in an ad hoc fashion. For periodic experimental designs, we propose a multisubject frequency domain brain mapping, which requires only the stimulation frequency, and consequently avoids subjective choices of HRF. We present some computational simulations, which demon- strate a good performance of the proposed approach in short length time series. In addition, an application to real fMRI datasets is also presented.

Identifying Multisubject Cortical Activation in Functional MRI: A Frequency Domain Approach