English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

ABSTRACT Objectives : In this study, we investigated the effect of Saposhnikoviae Radix on allergic responses in ovalbumin(OVA)-induced Allergic rhinitis(AR) mice.Methods : BALB/c mice were orally administrated with Saposhnikoviae Radi x water extract (SRW, 50 ㎎/㎏) or anti-histamine drug, Ketotifen (10 ㎎/㎏) as a reference drug, fo llowed by sensitization and challenge of OVA. Mice were measured clinical symptoms and the serum levels of hi stamine, IgE, IL-4, and IFN-γ, and observed histopathological changes of nasal mucosa H&E staining. Results : SRW significantly decreased rubs and the serum levels of hista mine, IgE, and IL-4, and then increased the serum levels of IFN-γ in OVA-induced AR mice, and inhibited histopathological changes of nasal mucosa with inflammation and the eosinophils infilteration. Conclusions : These data suggest that SRW has anti-allergic effect through t he inhibitory property of Saposhnikoviae Radix against allergic responses in allergic rhinitis. Key words : Saposhnikoviae Radix, anti-allergic effect, Allergic rhinitis, ovalbumin, ketotifen

Effects of Saposhnikoviae Radix on allergic responses in OVA-induced Allergic rhinitis mice