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The Influenza A virus belongs to the Orthomyxoviridae family. Influenza virusinfection occurs yearly in all countries of the world. It usually kills between250,000 and 500,000 people and causes severe illness in millions more. Over thelast century alone we have seen 3 global influenza pandemics. The great humanand financial cost of this disease has made it the second most studied virustoday, behind HIV. Recently, several genome-wide RNA interference studies havefocused on identifying host molecules that participate in Influenza infection.We used nine of these studies for this meta-analysis. Even though the overlapamong genes identified in multiple screens was small, network analysisindicates that similar protein complexes and biological functions of the hostwere present. As a result, several host gene complexes important for theInfluenza virus life cycle were identified. The biological function and therelevance of each identified protein complex in the Influenza virus life cycleis further detailed in this paper.

Host Cell Factors Necessary for Influenza A Infection: Meta-Analysis of Genome Wide Studies