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OBJECTIVES:  To investigate the predictive value of long non-coding RNA (lncRNA) H19 and the ten-eleven translocation enzyme 1 ( TET1 ) transcriptional expression in postoperative recurrence of uterine fibroids (UFs).    METHODS:  Seventy-five patients with UF, who underwent surgical treatment, were enrolled in the treatment group, and 60 healthy individuals were enrolled in the control group. The relative expression levels of lncRNA H19 and  TET1  mRNA in the serum and UF tissues were analyzed. The patients were further divided into a better curative (BC) group and a poor efficacy (PE) group to analyze the predictive value of lncRNA H19 and  TET1  and the independent risk factors affecting the recurrence of UF.    RESULTS:  Compared with the control group, lncRNA H19 expression levels were significantly higher, while  TET1  expression levels were significantly lower in the treatment group ( p &lt;0.001). The area under the receiver operating characteristic (ROC) curve (AUC) values of the two indicators for diagnostic importance were found to be 0.872 and 0.826, respectively. Compared with the PE group, lncRNA H19 expression levels were significantly lower, while  TET1  expression levels were significantly higher in the BC group ( p &lt;0.001). The AUC values of the two indicators for their predictive efficacy were 0.788 and 0.812, respectively. Logistic regression analysis showed that age, menarche age, maximum diameter of UFs, number of UFs, lncRNA H19 levels, and  TET1  levels were independent risk factors affecting UF recurrence. The AUC values of lncRNA H19 and  TET1  for their predictive value for postoperative recurrence were 0.814 and 0.765, respectively.    CONCLUSIONS:  The lncRNA H19 and  TET1  have high diagnostic and predictive efficacy for determining the postoperative recurrence of UFs.

clinics

Long non-coding ribonucleic acid H19 and ten-eleven translocation enzyme 1 messenger RNA expression levels in uterine fibroids may predict their postoperative recurrence