Proposed recommendations for antithrombotic prophylaxis for children and adolescents with severe infection and/or multisystem inflammatory syndrome caused by SARS-CoV-2

Hemostasis in children and adolescents: ontogenetic characteristics and impact on pediatric thromboembolism During phylogenetic evolution, living beings develop a regulatory hemostatic system for protecting the cardiovascular system. In humans, the hemostatic system has a peculiar ontogenesis, which consists of a dynamic evolutionary process deeply influenced by age. The term “developmental hemostasis” has been used since the 1990s to describe age-dependent changes in the hemostatic system, as seen in (). Children are physiologically protected from thromboembolic events due to a decreased [...]