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This study focuses on solid state physico-chemical properties of recently synthesized potential sensitizers for photodynamic therapy developed on a chlorophyll a platform. Pheophorbide a and chlorin e6 derivatives as well as two their glycol conjugates have been synthesized and identified via UV-Vis, NMR and mass spectra. The behavior of photosensitizers (PSs) in a solid state has been studied. They were found to be stable in inert atmosphere at least up to 520 K, the thermal stability decreases from phlorin to chlorin molecules and, especially, after their glycol substitution. The thermodestruction of macroheterocycles takes place after their melting. Both glycol conjugates form intramolecular H-bonds in two different conformations, what is confirmed by phase transitions on DSC curves and quantum-chemical analysis data.

Solid State Physicochemical Study of Chlorophyll a Derivatives and Their Glycol Conjugates