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El estudio se estructura en tres objetivos principales. En el primero, se categorizaron las alteraciones del metabolismo hidrocarbonado en pacientes con cirrosis, mediante un test de tolerancia antes, a los 6 y 12 meses tras el trasplante. En el segundo estudio, se comprobó el impacto de la diabetes en la morbimortalidad de una serie de pacientes sometidos a trasplante hepático y seguidos durante 10 años. En el tercero, se comparó el impacto del control de la glucemia en una serie de pacientes trasplantados en los que se aplicó tratamiento intensificado de la glucemia frente a una serie histórica con tratamiento convencional. Se observó una alta prevalencia de alteraciones del metabolismo hidrocarbonado que mejoraron tras el trasplante, la diabetes se asoció a mayor riesgo de rechazo del injerto y de eventos cardiovasculares, y los pacientes que fueron tratados con protocolo intensificado de su diabetes presentaron menor riesgo de rechazo del injerto.The study is structured in three main objectives. In the first one, the alterations of glucose metabolism parameters in patients with cirrhosis were categorized by a tolerance test that was performed before, at 6 and 12 months after transplant. The second study was performed to observe the impact of diabetes on the morbidity and mortality of patients undergoing liver transplantation and followed for 10 years. In the third study, the impact of glycemic control was compared in a series of liver transplant patients, in which intensive control was applied, with a historical series with conventional control. The main results were as follows: there was a high prevalence of altered glucose metabolism that improved after transplantation, diabetes was associated with an increased risk of graft rejection and cardiovascular events, and there was less risk of graft rejection in the series of transplant patients in which an intensive glycemic protocol was applied

Estudio de las alteraciones del metabolismo hidrocarbonado en pacientes cirróticos sometidos a trasplante hepático. Impacto del control intensivo de la glucemia durante la estancia hospitalaria