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It is of interest to document the inhibition of A2780 cell proliferation using Mollugo nudicaulis Lam. (M. nudicaulis) extract by MTT assay and by monitoring the CXCR4 and HER2 expression through RT-PCR analysis. Results shown that the n-hexane extract of M. nudicaulis have anticancer activity IC50 values of 32.46ą0.92 Ĵg/mL on A2780 cell lines. It is further found that the CXCR4 and HER2 mRNA and protein expression were significantly reduced in M. nudicaulis treated A2780 cell lines. Thus, the n-hexane extract of M. nudicaulis is a natural source of bioactive compounds as potential anticancer agents.

MTT assay based inhibition analysis of A2780 cells proliferation using Mollugo nudicaulis Lam. extract with CXCR4 and HER2 expression