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Autoradiography (ARG) has been used for quantitative analysis of the cerebral blood flow using 123 I-IMP, and the regional cerebral blood flow (rCBF) can be assessed more accurately with scatter and attenuation correction. Currently, the filtered back projection (FBP) method is generally used for image reconstruction. However, we anticipate obtaining more accurate rCBF by the ordered subsets expectation maximization method with collimator broad correction three dimensional ordered subsets expectation maximization (3D-OSEM). In the present study, we optimized the processing conditions to quantify rCBF using the 3D-OSEM method and compared them with the FBP method. Regarding the method, we determined the subsets and iteration, compared rCBF values using a profile curve, and compared them with the rCBF values obtained by the XeCT (Xenon-enhanced computed tomography)/CBF method. We found that in the 3D-OSEM method using 90 direction collection and 1.72 mm/pixel, the most accurate image was obtained around subset 9 and iteration 10. In addition, as compared to the profile curve and the XeCT/CBF method, the thalamus rCBF was high in the 3D-OSEM method with a good correlation with that of the XeCT/CBF. Accordingly, we concluded that the 3D-OSEM method can improve the decrease in rCBF due to blurring of the distance between the source (i.e., a structure located in the central part of the brain such as the thalamus and the collimator).

Application of Collimator Broad Correction Three Dimensional Ordered Subsets Expectation Maximization for Regional Cerebral Blood Flow Measurement