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This research evaluated the effect of Bothrops moojeni venom on neuromuscular activity and verified the anti-phallic potential of the J. elliptica starch in this model. The venom was obtained from snakes collected in the state of Tocantins, the protein profile evaluated in electrophoresis (SDS-PAGE), and the activity on the phrenic-diaphragm nerve of mice determined in 50 μg/mL of venom. The JeP, obtained by hand, was sieved in a sieve for granulometric analysis and concentrations of 100 and 1000 μg/mL were tested to verify its anti-phallic potential on the action of the poison. The following models were used: pre-venom addition of venom and after 15 min addition of JeP; post-poison addition of JeP and after 15 min the addition of poison; and pre-incubation for 30 min, of poison with JeP or commercial antivenom. The poison had proteins from 10 to 60 kDa, which induced 50% of neuromuscular activity block in 71.5 ± 8.9 min (T50). The pre-venom and post-venom models with JeP 100 μg/mL prolonged phrenic nerve activity time (100.9 ± 7.6 min and 97 ± 6.1 min, respectively). The results obtained for 1000 μg/mL and in the model of pre-incubation of the venom with JeP 100 (78.2 ± 9.2); 1000 μg/mL (86.5 ± 8.9) and with commercial botropic antivenom (80.2 ± 14.1), did not interfere with the activity of the venom on the phrenic nerve. Bothrops moojeni venom induces neuromuscular block and the lower concentration of the starch caused a protective effect on the junction, before and after the administration of the venom.

Neuromuscular block induced by Bothrops moojeni snake venom and the effect of Jatropha elliptica starch