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We report two cases of unilateral adrenal hyperplasia with contralateral renal cell carcinoma. First case was a 66-year-old man with right renal mass who came to our hospital for study. Although no major symptoms were complained, blood pressure was consistently above normal. Hypokalemia, low plasma renin activity and high plasma aldosterone level were detected. CT revealed that he had a right renal mass and a left adrenal tumor. Preoperative diagnosis was right renal tumor and primary aldosteronism due to left adrenal adenoma. Second case was a 59-year-old man with right renal mass who also came to our hospital for study. He also had a left adrenal tumor, however his blood pressure was normal and serum hormonal analysis showed normal adrenal cortical function. Preoperative diagnosis was right renal tumor and non-functional left adrenal adenoma. Two patients were performed right radical nephrectomy with contralateral adrenarectomy. Pathological diagnosis were right renal cell carcinoma and left adrenocortical hyperplasia. One Patient clinically showed primary aldosteronism and the other had no clinical symptoms. These patients were rare cases with unilateral adrenal hyperplasia.

TWO CASE REPORTS OF UNILATERAL ADRENAL HYPERPLASIA WITH CONTRALATERAL RENAL CELL CARCINOMA