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Cell adhesion molecules (CAMs) have been considered to play key roles in cancer metastasis through binding of cancer cells to the endothelial cells or matrix. We have found that constitutive expression of E-selectin, ICAM-1 (intercellular adhesion molecule-1) and VCAM-1 (vascular cell adhesion molecule-1) on the cell surface of prostate cancer cell lines, PC-3 LNCaP, and DU145. In an attempt to explain the highly metastatic potential of these cells, we investigated expression of CAMs. Since these expressed CAMs are known to be regulated by a transcription factor NF kappa B. We have examined if NF kappa B is activated in these prostateccell lines.

ACTIVATION OF NUCLERA FACTOR-^|^kappa; B AND CONTROL OF THE EXPRESSION OF CELL ADHESION MOLECULES IN HUMAN PROSTATE CANCER CELLS