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Results of a total of 46 pediatric (mean age; 9.0 years), living-related, cyclosporine-treated renal allograft recipients were analyzed retrospectively to study 1), the effects of an acute rejection on the long-term allograft function and 2), the relationship between the cyclosporine blood levels and the frequency of acute rejections. In addition, sequential allograft biopsies (100 days, one, two and three years post-transplant) were performed in all cases to see if clinical symptoms correlated with histological changes.

BLOOD LEVELS OF CYCLOSPORINE, ACUTE REJECTIONS AND THE PROGNOSIS OF THE ALLOGRAFTS IN PEDIATRIC RFNAL ALLOGRAFT RECIPENTS