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Direct cholangioscopy (DC) provides high-quality endoscopic visualization of the biliary mucosa and has gained momentum in recent years, given the staggering technological and technical advancements. However, validated and/or conceptual quality indicators which are increasingly proposed for various endoscopic procedures remain poorly defined, focusing on pre-defined clinical targets (e.g., indeterminate strictures as per endoscopic retrograde cholangiography and/ or endoscopic ultrasound/other imaging findings) or on scope advancement up to the hilum. Thus, there is widespread consensus on presumed procedural completeness, i.e., advancement, up to a pre-defined target lesion and/or the liver hilum. By contrast, visualization of the most distal part of the common bile duct, i.e., the transitional zone from the biliary to the papillary mucosa, has been neglected in practice and research, mostly because of technical difficulties in stabilizing the endoscopic vision because of the sharp angulation of the duodenum-bile duct axis. A novel quality indicator of DC, described in its freehand fashion without ancillary techniques, is being proposed and illustrated: the “bilio-papillary Z line” reminiscent of its more easily accessible esophago-gastro-duodenoscopy counterpart. A 360° visualization of the bilio-papillary junction, in particular its medio-cranial aspects, remains difficult to achieve with currently established techniques (Fig. 1A, B). Likewise, because of prolapsing papillary mucosa, adequate endoscopic vision of the bilio-papillary transitional zone may become blurred (Fig. 1C), highlighting the need for technical advancements to gently flatten abundant papillary mucosa comparable to, though less aggressive than, endoscopic papillary large balloon dilation (Fig. 1D). Further research on this topic and future technical/technological refinements, e.g., dedicated cap-assisted freehand-intubated cholangioscopy as is in clin-

The “Bilio-Papillary Z Line”: Proposal for a Novel Quality Indicator of Direct Cholangioscopy