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Postulate of our research issue is based on the argumentation the correlation diffuse damage of neuronical and non neuronical subcortical structures weakened vascularization during the longer premorbid period with the clinical manifestation of cognitive dysfunction. The main aim of our researching is argumentation the atrophy subcortical brains structures and connection with cognitive dysfunction by the extent to the demented and brain mnestic deterioration. Research was carried out in the two researched groups of patients treated in hospital, A and B, that controlled themselves as well. Both groups consisted of 40 patients both sexes aged 50 to 70 years. Results of our research confirmed that cognitive functioning was damaged to all patients with determined subcortical brain, s ischemia and reduction of the neuronical and non neuronical subcortical structures diagnosed by the visualised imaging diagnostic methods. Dysfunction of cognition according to difficulty is the reciprocal psychometric confirmed scope of subcortical atrophy, or the reduction of the brain, s structures

The size of diffuse damage of both neuronic and non-neuronic structures correlated with cognitive disfunction