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There has been an evidence of use of natural substances against tumors since ancient times as confirming records originate from Russia, India, China and Japan. Natural substances with antitumor effects could be used as basic or adjuvant therapy. There are antitumor substances which have found way in clinical use e.g.. Vinca rosea (vinca alkaloids), Camptotheca acuminata (camptothecin), peltatum (epipodophyllotoxins), Taxus brevifolia (paclitaxel, docetaxel). There are other plants containing large groups ofchemically active principles, among which some substances have been studied more thoroughly for antitumor activity as are flavopirodol, homoharingtonin, beta lapachon, flavopiridol, homoharringtonine, beta lapachone, combretastatin etc. Some species of fungi and microorganisms represent also the source of antitumor substances. Among some mushrooms which contain antitumor substances are also some edible species (Agaricus bisporus, Agaricus blazei, Pleurotus ostreatus, Lentinus edodes, Grifola frondosa i dr.). In this work we presented a limited number of natural sources of antitumor substances, but the number of those in clinical practice as well as of those which are being currently studied are constantly growing, as a consequence of increasing presence of different malign diseases.

Some natural sources of substances with antitumor effects