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Bone fractures frequently occur in elderly persons even after low-energy trauma. Given that the young individuals would not sustain a fracture under such conditions, it is clear that the main cause of easy bone fracturing originates from the structural and compositional characteristics of the aged bone itself. Observing bone, from macro- to nano-level, shows us the complexity of bone hierarchical organization and reveals various determinants of bone strength. In particular, recent studies focusing on bone at nano-scale revealed distinctive features of the bone matrix that could provide additional explanation for the increased bone fragility in advanced age, independent from age-related effects at other levels of bone hierarchical structure

'GOING NANO' in the field of osteology: Is bone fragility already determined at the level of bone mineralized matrix?