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Objective. Relationship between Graves’ disease and vitamin D deficiency is a challenging matter and some of researchers had suggested the role of vitamin D deficiency in the pathogenesis of Graves’ disease. We designed this study to evaluate serum level of vitamin D in Graves’ disease. Methods. During a cross-sectional study in 2014, 27 patients with Graves’ disease and 29 healthy subjects were enrolled. From all of the patients and healthy group intravenous blood samples for assessment of serum vitamin D levels were taken. Serum level of vitamin D of all of patients and healthy group were compared with each other. Serum vitamin D level lower than 15 ng/ml was considered as vitamin D deficiency. Serum vitamin D levels between 1530 and 30-50 ng/ml were considered as vitamin D insufficiency and normal vitamin D levels respectively. Results. The mean age in Graves’ patients and healthy group were 41.23 ± 2.58 and 34.40 ±1.44 years respectively (P=0.02) and there was a significant difference between the age in the two groups. 77.8 and 58.6% of Graves’ patients and healthy groups were females respectively (P=0.12). Serum level of vitamin D in Graves’ patient was 18.04±1.92 ng/ml and in healthy controls was 17.15±2.06 ng/ml and there was not a statistically significant difference in vitamin D levels between the two groups (p=0.75). Vitamin D status did not differ between the two groups of the study (p value=0.92). Conclusion. According to our study, there is no association between serum vitamin D levels and Graves' disease.

Comparison of serum levels of vitamin D in Graves' patients and healthy individuals