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Pharmacodynamic Approach for Proving Equivalence of Two Ophtalmic Solutions Containing Brimonidine Tartarate 0.2% in Healthy Volunteers A Ruska Valcheva Hristova1, Irenna Stojanova Demircheva1, Andrey Dimitrov Petrov2, Emil M. Gatchev2, Ursula Th yroff -Friesinger3, Wolfram Hagen Richter4, Rossen Krumov Koytchev4 A 1 Medical University of Sofi a, Clinic of Ophthalmology, University Hospital ”Tsaritsa Joanna-ISUL”, Bulgaria 2 Medical University of Sofi a, Department of Clinical Pharmacology and Th erapeutics, University Hospital ”Tsaritsa Joanna-ISUL”, Bulgaria 3 Hexal AG, Holzkirchen, Germany 4 Cooperative Clinical Drug Research and Development AG, Hoppegarten, Germany

Pharmacodynamic approach for proving equivalence of two ophtalmic solutions containing Brimonidine Tartarate 0.2% in healthy volunteers