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The first prosthesis developed for this purpose, called PLAATO, was tested early in the last decade by Horst Sievert et al.4 and consisted of a nitinol structure, covered by an expanded polytetrafluoroethylene (ePTFE) occlusive membrane. The clinical study published in 2002 showed that the concept of percutaneous LAA occlusion was feasible; however, the prosthesis use was discontinued in 2005, due to the considerable number of complications such as cardiac tamponade, residual leaks, prosthesis protrusion towards the atrial cavity and, in some cases, lack of neo-endothelization of the prosthesis with formation of local thrombi.5 On the other hand, the experience obtained with the implantation of this prosthesis was important for the development of more effective devices.

Percutaneous Occlusion of Left Atrial Appendage: Growing Clinical Experience and Lack of Multicenter Randomized Clinical Trials