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Prothrombin Complex Concentrates (PCCs) contain clotting factors that are vitamin K-dependent at a concentration 25 times greater than the plasma and are classified into compounds of three or four factors according to the presence of factor VII (FVII). When compared to frozen fresh plasma (FFPs), those are more effective, and can be administered quickly and at low doses to achieve the desired effect. The safety profile of PCCs is still uncertain because its adverse events, especially thromboembolic ones, have been reported with its use. PCCs were developed initially for the treatment of hemophilia B. Today, its main indication is the emergency reversal of anticoagulation induced by vitamin K antagonists. After the creation of specific concentrate factors, PCCs have been used in hemophiliacs, in its activated form, for the prophylaxis of bleeding in the peri-operative period of patients who are carriers of antibody inhibitors. Several studies demonstrate good results with the use of PCCs in dilutional coagulopathy induced by trauma and cardiac surgery. Reduced bleeding and decreased need for blood transfusions were observed when administered in association with fibrinogen concentrate; however, high-impact studies are still needed to prove Prothrombin Complex Concentrate and its applications in the operating room Erick Martins Faria de Abreu1, Leonardo Saraiva Guimarães de Oliveira2, Pablo Martins Biagioni de Menezes3, Jaci Custódio Jorge4 O Concentrado de Complexo Protrombínico e suas aplicações na sala de cirurgia DOI: 10.5935/2238-3182.2014S015