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Background: Left ventricular dysfunction and functional capacity (FC) are important markers of morbidity and mortality in Chagas heart disease (CHD), however, the relationship between these clinical parameters remains controversial. Objective: To verify the association between FC and systolic and diastolic functions of the left ventricle in CHD patients. Methods: Thirty-five CHD patients (47.11±8.15 years) underwent clinical evaluation, echocardiography and Cardiopulmonary Exercise Testing (CPET) and were classified into two groups: dilated group (dilated cardiomyopathy) and non-dilated group (preserved systolic function). The left ventricular ejection fraction (LVEF), E/e’ ratio and peak oxygen uptake (VO 2peak )were considered. Statistical analysis was carried outwith Pearson or Spearman correlation tests and backward multivariate linear regression analysis was performed to assess the effect of LVEF and E/e’ ratio on VO 2peak . Results: In the overall study population, there was a significant correlation between VO 2peak and LVEF (r=0.536; p=0.001) and a significant negative correlation between VO 2peak and E/e’ ratio (r=-0.399; Relationship between left ventricular ejection fraction and e /e’ ratiowith functional capacity in chagas heart disease Joice Coutinho de Alvarenga1, Pedro Damião Jansen1, Vitória Emilia Gomes Marques1, Henrique Silveira Costa2, Giovane Rodrigo de Sousa2, Aline Cristina de Souza2, Maria do Carmo Pereira Nunes2, Márcia Maria Oliveira Lima3, Manoel Otávio da Costa Rocha4 Relação entre a fração de ejeção do ventrículo esquerdo e razão e/e’ com a capacidade funcional na cardiopatia chagásica DOI: 10.5935/2238-3182.20140118

Relationship between left ventricular ejection fraction and e/e' ratiowith functional capacity in chagas heart disease