Profile of resistance to antituberculosis drugs in a reference hospital in the State of Minas

Tuberculosis is a serious, infectiousand transmissible disease of great relevance to global public health. The ability to acquire resistance to antimicrobials of choice for therapy has hampered the treatment of TB patients. The aim of this study was to verify in a referral hospital in Juiz de Fora, Minas Gerais, the resistance profile of mycobacteria isolated from patients with tuberculosis from the modification of the treatment regimen 2009. A retrospective analysis was performed on 45 positive cultures from patients with pulmonary tuberculosis and susceptibility testing from January 2012 to May 2014. Of the 45 positive cultures from were identified M. tuberculosis: 30 (67%) were sensitive to all drugs tested (streptomycin, isoniazid, rifampicin, ethambutol and pyrazinamide). The monorresistente 3 (7%), with resistance to: streptomycin (2.33%), isoniazid (2.33%) and rifampicin (2.33%). The that presented multidrug resistance accounted for 10 cases (22%), with resistance: isoniazid + rifampicin (13.2%), rifampicin + isoniazid + streptomycin (2.2%), rifampicin + isoniazid + ethambutol (4.4%), isoniazid + rifampicin + streptomycin + ethambutol (2.2%). Finally, the matched polirresistências 2 (4%) with resistance: Profile of resistance to antituberculosis drugs in a reference hospital in the State of Minas Nilma Maria José de Araújo Mendes1, Ronaldo Rodrigues da Costa2, Anna Marcella Neves Dias3, Camila Balbino Lopes4, Daniele Maria Knupp de Souza5, Marcio Roberto Silva6, Harleson Lopes de Mesquita7 Perfil de resistência a fármacos antituberculose em um hospital de referência do Estado de Minas Gerais DOI: 10.5935/2238-3182.20140072