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Fungos endofíticos representam uma fonte rica de produtos naturais novos e bioativos. Eles colonizam um habitat ecológico praticamente inexplorado e seus metabólitos secundários são particularmente ativos, possivelmente devido às interações metabólicas com seus hospedeiros. No decorrer de nossas pesquisas na investigação de novos e bioativos compostos de fungos endofíticos da flora brasileira, foram estudas as espécies Alibertia macrophylla, Caseria sylvestris, Ocotea corymbosa, Senna spectabilis, Piper aduncum, Cryptocaria mandioccana, Xylopia aromatica e Palicourea marcgravii. Quarenta e dois produtos naturais foram obtidos e suas estruturas determinadas com base nas análises dos dados espectrais de RMN 1D e 2D. Os compostos foram submetidos à avaliação das atividades antifúngica, antioxidante, anticolinesterásica e anticancerígena. DOI: 10.5935/1984-6835.20130036Endophytic fungi are a rich source of new and biologically active natural products. They colonize a relatively unexplored ecological habitat and their secondary metabolism is particularly active, presumably due to metabolic interactions with their hosts. In the course of our continuing investigations for new and bioactive compounds from endophytic fungi from brazilian flora Alibertia macrophylla, Caseria sylvestris, Ocotea corymbosa, Cassia spectabilis, Piper aduncum, Cryptocaria mandioccana, Xylopia aromatica and Palicourea marcgravii were investigated. Forty two natural products were isolated and their structures were established on the basis of comprehensive spectral analysis, mainly using 1D and 2D NMR experiments. The compounds were tested in their antifungal, antioxidant, anticholinesterasic and anticancer activities. DOI: 10.5935/1984-6835.2013003

Endophytic Fungi: An Unexplored and Sustainable Source of New and Bioactive Natural Products