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In the few randomized control trials (RCT) published about the new way of running the PGS (PGS-new), the lessons of reproductive evidence-based medicine are often ignored. The “n” sample is always lower than required and the concept of intention-to-treat analysis (ITT) is forgotten. It should be remembered that all randomized patient need to be analyzed independently of protocol deviations, withdrawal, and anything that happens after randomization. The patients should not be randomized by the number of embryos. Usually, in the new-PGS there are a minimum number of viable blastocysts as a rule to initiate patient randomization.

Seven Reasons To Be Concerned About the Use of the New Preimplantation Genetic Screening (PGS)