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This study was carried out to assess the role PGL-1 antibodies may have to play in assisting with early diagnosis in close contacts of leprosy patients. Blood samples were collected from patients and contacts. It was found that 6.9% of index cases and 1% of healthy contacts were positive for PGL-1 antibody. None of the healthy contacts developed clinical leprosy and all had become seronegative at follow-up. We conclude that screening for PGL-1 antibodies has a limited role in the screening of healthy contacts and may not be of use in low endemic areas.

The role of IgM antiphenolic glycolipid-1 antibodies in assessing household contacts of leprosy patients in a low endemic area