English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The effect of c10fazimine and 6 analogues (B 369 1 , B 3 7 1 3 , B 3640, B 3648, B 720 and B 749) on the viabi l i ty of Mycobacterium /eprae was tested i n a rapid, radiometric, ill vitro assay. Thi rteen human and I armadi l lo-derived freshly-extracted M. /eprae, maintained in peritoneal macro phages, incorporated 3H -thymidine to significant levels as compared to paral lel cu l tures with heat-k i l led baci l l i . Exposure of such cul tures to c10fazimine for 48 h showed significant inh ibi t ion of the radiolabel uptake without any adverse effects on the host macrophages. A sharp l i near i ncrease i n i nhibi t ion was observable at concentra­ tions from I to 10 ng/ml , with a plateau up to 40 ng/m l . Further i ncreases of drug concentration up to 1 00 ng/ml showed marginal increase i n the percentage inhibit ion of 3H-thymidine i ncorporat ion . The analogues tested showed levels of inhibit ion s imi lar to that of c10fazimine when left for 72 h and 1 5 days i n M. /eprae macrophage cul tures . However, they were less effect ive than c10fazimine when tested for the shorter duration of 48 h at the lower concentration of 5 ng/m l .

Rapid, radiometricin vitroassay for the evaluation of the anti-leprosy activity of clofazimine and its analogues