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The self-admin i s t ra t ion of on ce-weekly d oses of 300 mg Dapsone ( D DS ) by leprosy pat ien ts in lhe M w anza region of Tanzania was mon i to red using the urine-test method d escribed b y El lard e r a i. ( 1 9 7 4a ) . D D S/ c reat in ine rat ios were de termined on u rine sam ples voided by 65 superv ised le p rosy pat ients on each of 7 successive days fol lowing the ingest ion of 300 mg D D S . The method w as then app lied to ur ine sa m p les col lected by means of surp rise visi ts to t h e homes of 1 58 o u t-pat ients 2 days after the day on whic h a 300 mg dose of D D S should have been taken . The ex t en t o f DDS self-ad minist ration by the ou t-pat ienls was est imated by com paring the results wi th t h ose obtained fro m cont rols given supervised D D S doses and from su bjects not laking D DS. Significan t a m ounts of D D S were not detected in the urine sa m p les col lected fro m 3 0% of the out-pat ien ls . F urthermore the average D DS/creat in ine ratios of lhe u rine sa m p les of the other out-pat ients were significant ly lower t h an those from the supervised con trols . The i m pl icat ions o f these find ings t o the t reat ment of l eprosy in the M wanza region and t heir relevance to olher l eprosy con lrol schemes is discusse d .

Weekly Self-Medication of Leprosy Patients Monitored by DDS/Creatinine Ratios in Urines