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An open trial to assess the value of c10fazimine in the management of cases of lepromatous leprasy with recurrent lepra reaction and those who are sulphone sensitive was commenced in February, 1 9 7 3 . Thalidomide was used as the drug in the contrai subjects. U p to the end of August, 1 9 74 , 6 1 cases have been ad mitted into the study. In the majority of instances the drug had been found to be effective . I n 3 instances c10fazimine failed to confer beneficiai effects. Six cases in whom the m aintenance dose of the drug was stopped after 52 weeks of continued control of the reactive state , have not revealed any recurrence of reaction.

Open Trial with Clofazimine in the Management of Recurrent Lepra Reaction and of Sulphone Sensitive Cases: A Preliminary Report