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I n the present connection it is necessary to mod i fy or extencl certain of the definit ions of t he Memorial Con ference c lassification in the l ight of present knowledge, and seems desi rable to add certain others for the sake of completeness. Th'e most important of the proposed modifications are the precision of " leproma " and the reduction of " l eprot ic " to i ts general sense. " Macule " i s retained i n its special sense, which leprosy workers will undoubtedly continue to give it in spite of the protests of dermatologists . The most important added definition i s " lepride ," which was unfor­ tunately ove rlooked by the conference. Leproma. This term appl ies excl usi vely to the l es ions of various orgal1S that are characteristic o f the cutaneous type o f l eprosy. The condition is a gran lllomatolls one i n whicK reaction on the part o f th e invaded t issues is min ima! . The essential h i s tologi cal f·e ature i s an accumulation o f " lepra cells , " which may show l i ttle differentiation f rom thei r original form ( th e macrophage) , o r may contain globi , or may ha V'e undergone m ul t ipl e vacuolation to produce the so.-called Vi rchow cells , o ften mult inucleate. These cells conta i n lepros'y 'bacifli in considerable and o f ten great nu mbers , th ough they also occur i n other cell s . Lepromatous lesions in the skin may be 5 0 sl igh t as to be imper­ ceptible, ranging up to marked, exten s i v e i nfi l t rat ions or conspicuous nodular masses . As a rule they are mqre i l l -defin ed and d i ffusely out­ l ined 'than the leprides , and they do not exhib i t the same tendency to radial extension or the same changes o f col or or sensation . Lepride. This term i s applied to the discrete macular les ions o f the skin that a re characteristic o f neural l eprosy. The leprides vary greally in appearance, s ize , and as regards elevation ; they may be Aat , or even depressed ( th rough atrophy) , or markedly th ickened ; th ey may be smooth-surfaced or very i r regular ("granular ," " pebbled " or micro" papulate) ; they tend to enl arge rad ial ly and to merge with adj acent ones, and to undergo central resolut ion. Dimin ution o f sensory perception, partial o r complete , i s a typical feature, thollgh its deve lopment may be delayed . The definitely infiltrated leprides, at least, are granu­ lomatous , the essential feature being the nonspec i fic " tube rculoid " change , with which there usually i s banal chronic inA ammatory infil., tration o f variable degree . Associated cutan eous nerves may be

A Proposed Revision of the Memorial Conference Classfication of Leprosy