Open AccessOxidative stress and decreased tissue HSP70 are involved in the genesis of sepsis: HSP70 as a therapeutic target
Author(s) -
Maicon Machado Sulzbacher,
Mirna Stela Ludwig,
Thiago Gomes Heck
Publication year - 2020
Publication title -
revista brasileira de terapia intensiva
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.431
H-Index - 19
eISSN - 1982-4335
pISSN - 0103-507X
DOI - 10.5935/0103-507x.20200084
Subject(s) - oxidative stress , sepsis , medicine , hsp70 , pathophysiology , biomarker , immunology , organ dysfunction , extracellular , heat shock protein , microbiology and biotechnology , biochemistry , biology , gene
Sepsis is a systemic infection that causes multiple organ dysfunction. HSP70 is a protein responsive to cell stress, in particular oxidative stress. Therefore, this literature review sought to investigate the roles of HSP70 and oxidative stress in the pathophysiology of sepsis and the possibility of HSP70 as a therapeutic target. HSP70 exerts a protective effect when located in cells (iHSP70), and its decrease, as well as its increase in the extracellular environment (eHSP70), under oxidative stress is a biomarker of sepsis severity. In addition, therapies that increase iHSP70 and treatment with HSP70 promote sepsis improvement.
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