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Pro-inflammatory markers play a significant role in the disease severity of patients with COVID-19. Thus, anti-inflammatory therapies are attractive agents for potentially combating the uncontrolled inflammatory cascade in these patients. We designed a trial testing tocilizumab versus standard of care intending to improve the outcomes by inhibiting interleukin-6, an important inflammatory mediator in COVID-19.

revista brasileira de terapia intensiva

Rationale and design of the “Tocilizumab in patients with moderate to severe COVID-19: na open-label multicentre randomized controlled” trial (TOCIBRAS)