Open AccessAn Efficient and Chemoselective Deprotection of Aryltert-Butyldimethylsilyl (TBDMS) Ethers by NaCN
Author(s) -
Xue-jun Qiao,
Xiao Hou,
Wu-hong Fang,
Xuefei Bao,
Guoliang Chen
Publication year - 2015
Publication title -
journal of the brazilian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.337
H-Index - 70
eISSN - 1678-4790
pISSN - 0103-5053
DOI - 10.5935/0103-5053.20150342
Subject(s) - aryl , chemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , alkyl
Phenolic tert-butyldimethylsilyl (TBDMS) ethers can be deprotected to yield phenols in excellent yield using sodium cyanide (NaCN) as catalyst in ethanol. The deprotectation of various phenolic TBDMS ethers were found to be very convenient, fast, high yielding and chemoselective.
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