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A investigacao quimica das culturas do fungo Marasmiellus ramealis resultou na primeira isolacao de onze compostos incluindo dois novos sesquiterpenoides do tipo eudesmano 14(10→1)abeo-eudesmano-13-hidroxil-11-eno, 14(10→1)abeo-eudesmano-11,13-diol, e o novo derivado de meleina (R)-(-)-5-etoxicarbonil meleina. A atividade inibitoria da aceticolinesterase (AChE) dos dois primeiros compostos foi avaliada, que mostraram ser ativos com uma porcentagem de inibicao de 29 e 41%, respectivamente, em uma concentracao de 100 µmol L-1. Chemical investigation on the cultures of the fungus Marasmiellus ramealis resulted in the first isolation of eleven compounds including two new eudesmane-type sesquiterpenoids 14(10→1)abeo-eudesmane-13-hydroxyl-11-ene, 14(10→1)abeo-eudesmane-11,13-diol, and the new mellein derivative (R)-(-)-5-ethoxycarbonyl mellein. The first two compounds were evaluated for their inhibitory activity against acetylcholinesterase (AChE), and proved to be active with a percentage inhibition of 29 and 41%, respectively, at a concentration of 100 µmol L -1 .

Chemical Constituents from Cultures of the FungusMarasmiellus ramealis(Bull.) Singer