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The clinical effects of vitamin E have been investigated in 7 cases (3 adolescents and 4 adults) of purpura due to vascular changes caused by infection, drugs or of unknown etiology. Marked clinical improvements were observed following the oral administration of vitamin E (400 to 600mg of α-tocopherol nicotinate per day) in all cases. Six out of 7 cases showed remarkable improvement of petechiae following the vitamin E therapy alone. Complete disappearance of petechiae was observed following the administration of vitamin E for 5 days in 2 cases, 14 days in 4 cases and 21 days in 1 case, along with the improvements of other clinical symptoms.

The Clinical Effects of Vitamin E on Purpuras due to Vascular Defects