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Incorporation of serine-3-14C to serum albumin and globulin fractions along with that of glycine-2-14C to heme was studied in phenylhydrazine injected rats. There was an increase in albumin and heme syntheses and a decrease in globulin synthesis. Serum transaminases and cholinesterase activities remained more or less unchanged. Vitamin B12 levels were decreased in liver and kidney but increased in blood. All these results were discussed in the light of a lesser liver damage resulting due to an insufficient dose of phenylhydrazine. The protective action of glucose cycloacetoacetate hydrolysate, reduced glutathione and vitamin B12 in all the derangements were also contemplated.

Studies on Protein Synthesis and Vitamin B12 Status in Phenylhydrazine Treated Rats