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Evaluation of the immuno modulatory activity methanolic extracts of leaves and flowers of Pongamia glabra Vent. in cyclophosphamide induced myelosuppressed mice. Methanolic extracts of leaves and flo wers of Pongamia glabra Vent. at the doses of 250mg/kg and 500mg/kg p.o. were ad ministered for 13 days to normal adult albino mice of either sex and cyclophosphamide (30mg/kg i.p.) was in jected on 11 th ,12 th and 13 th days 1 hour after the administration of the treatment with extract. On 14 th day blood was collected by retro o rbital puncture and the activity was evaluated by determining the RBC, Hb%, Platelet, total WBC and differential counts. Methanolic extracts of leaves and flowers of Pongamia glabra Vent . showed dose dependant highly significant(p<0.001) counteracting effect to cyclophosphamide induced reduction in total WBC, DLC and platelet counts and significant (p<0.01) effect to that of reduction in RBC counts and Hb%. The significant immunostimu lant activity of the methanolic ext racts of Pongamia glabra Vent . leaves and flowers at the doses of 250mg/kg and 500mg/ kg p.o. in cyclophosphamide induced myelosuppression may be attributed towards the presence of bioactive components, viz.- saponins, sterols, tannins and flavonoids in the ext racts.

Preliminary Investigation for Immunomodulation of Methanolic Extracts of Leaves and Flowers of <i>Pongamia Glabra</i> Vent. in Mice Model