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The efficacy of plants in treatment of various diseases has led to the development of presentable and accepatble herbal formulations. This study evaluated the suitability of different binders in the formulation of dried aqueous leaf extract of Telfairia occidentalis (TOLE) tablets. Granules were prepared by wet granulation using polyvinyl pyrollidone (PVP), corn starch (CS) and gelatin (GEL) at 5 %w/v and then compressed into tablets. Flow properties of granules; angle of repose, Hausner ratio and Carr’s index were determined, mechanical properties of tablets; hardness, friability and disintegration time were evaluated and anti-anaemic assessment of the optimized tablet was carried out using standard methods. Results show that TOLE and the granule formulations possessed good flow properties. Tablet hardness was 5.22, 5.18, 4.40 kgF for GEL>CS>PVP respectively; friability values were 0.00, 0.20 and 0.34 % respectively. Tablets disintegrated between 28 and > 60 min; only those prepared with PVP disintegrated within official specified time. Optimized tablet was comparable with TOLE in improving haematological indices of mice. All the binders produced robust tablets but PVP is considered the most suitable, in vivo study revealed TOLE retained its activity in the formulated tablet suggesting the formulation can be used as an oral anti-anaemic supplement. BY 4.0 Open Access 2020 – University of Huddersfield Press

Formulation and antianaemic evaluation of the tablets containing Telfairia occidentalis aqueous leaf extract