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The formation and progression of drusen was studied in the retinas of Fisher rats. The incidence of drusen increased with age. More numerous and advanced lesions were formed in males than in females. In general, there were more lesions in lower peripheral retina than upper peripheral retinas. Early lesions appeared as an accumulation of amorphous material between the retina pigment epithelium and Brush's membrane, which later led to the separation and disruption of retinal pigment epithelium. Increased thickness of Bruch's membrane, areolar atrophy of retinal pigment epithelium, and choroidal neovascularization were evident in advanced lesions. Drusen have been caused by many factors. To understand the etiology of these lesions, it is important to study the effect of each factor. The changes reported in this study are specifically age-related.

Drusen, an Age Related Change in the Retina of the Fisher Rat